Regeneration, Redefined
Aging and skin renewal are both continuous processes—neither happens overnight. Modern aesthetic medicine now recognizes that the most effective rejuvenation doesn’t rely on artificial volume but on the body’s natural healing process. Among the most studied advances in regenerative medicine, Platelet-Derived Growth Factor (PDGF) stands out for its ability to renew skin from the cellular level outward, stimulating the very mechanisms that maintain elasticity, hydration, and tone.
At Trubella Medspa and Aesthetics in Dedham, PDGF therapy is part of a refined approach to skin rejuvenation, backed by science and designed for patients who value long-term results. Our expert team offers PDGF as both a standalone treatment and a complement to our other skin rejuvenation procedures for comprehensive improvement in skin health and texture.
Platelet-Derived Growth Factor (PDGF) is one of several growth factors found naturally in the body’s platelets. When platelets are activated, they release PDGF along with other regenerative messengers like epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF), all of which help restore the skin’s structural integrity. It triggers cell growth, tissue repair, and the formation of new blood vessels, critical elements of healthy skin and wound healing.
In aesthetics, PDGF is isolated from a patient’s blood, a process similar to PRP therapy, and then applied or injected into targeted areas. Once in the deeper layers of the skin, PDGF stimulates dermal fibroblasts and smooth muscle cells, promoting collagen production, elastin formation, and overall tissue regeneration. The result is smoother, healthier skin supported by renewed strength from within.
Renewal Comes From Within
PDGF strengthens the skin from the inside out. It restores the structure that gives skin its firmness and tone while improving how it holds moisture and heals itself. Over time, the surface looks smoother, color more even, and texture more consistent.
Key benefits include:
PDGF is great for patients looking to keep their skin in good condition. The treatment works across skin types and ages, addressing early signs of aging, texture issues, or general dullness.
Candidates often include those noticing early signs of uneven texture, dry skin, or mild skin laxity. It can also be used to aid tissue repair in areas affected by acne scars, sun damage, or fine lines. During consultation, your Trubella specialist will evaluate your overall health, skin quality, and aesthetic goals to determine if PDGF is the right choice or if it should be paired with another treatment such as platelet-rich plasma (PRP) or microneedling for enhanced results.
PDGF signals the skin to rebuild damaged tissue. By activating fibroblasts and renewing the extracellular matrix, it helps smooth areas where scars once sat deeper in the skin.
With regular collagen renewal, the skin regains flexibility and a finer surface. The result is a more even tone and a texture that feels closer to its younger state.
Too much sun breaks down collagen and slows the skin's natural repair process. PDGF reverses that process and encourages new cell growth.
By stimulating hyaluronic acid and micro-circulation, PDGF helps dry skin hold moisture again. The skin looks more alive and feels less rough.
Your Skin, Your Plan
At Trubella Medspa and Aesthetics, every treatment begins with a consultation. Your provider will review your medical history, discuss your skin concerns, and evaluate your skin condition to design a plan tailored to your goals.
Before your appointment, you might be asked to skip blood-thinning supplements, limit alcohol or caffeine the day before, and arrive with a clean face. These simple steps reduce redness and help your skin absorb the treatment more effectively. The goal is to set up the best conditions for your skin to respond and heal quickly.
The treatment begins with a small blood draw, similar to what’s done for PRP therapy. The sample is processed to separate a higher concentration of platelets containing alpha granules, which release PDGF and other growth factors upon activation.
Your provider then applies or injects the prepared PDGF serum into the targeted treatment area—either topically (following microneedling) or through direct PDGF injections. In some cases, it’s layered with hyaluronic acid or used alongside mesenchymal stem cell–derived serums for advanced cellular regeneration.
The entire procedure typically takes under an hour. Most patients describe it as comfortable thanks to a gentle numbing agent applied beforehand.
There’s little downtime with PDGF. Some redness or faint swelling can show up after treatment, especially if it’s paired with microneedling, but it usually fades within a day. Keeping the skin clean and hydrated helps it recover smoothly. Avoid exfoliating or heavy products for a short while, then return to your regular routine. Makeup can usually be worn the next day.
Following your provider’s aftercare plan helps sustain the regenerative process and encourages continued collagen production for weeks afterward.
Because PDGF works at the cellular level, results appear progressively. Most patients notice improved skin tone and texture within three to four weeks, with continued enhancement as collagen and elastin fibers strengthen. Depending on your skin concerns and overall treatment plan, results can last several months, often extended through maintenance sessions or combination therapies.
PDGF’s regenerative properties make it fit easily into Trubella’s broader approach to skin health. It enhances the work of other treatments by supporting the deeper repair that gives results their staying power.
Pairing PDGF with Microneedling elevates collagen remodeling and speeds recovery. The tiny needles create microchannels that allow platelet-derived growth factor to reach the deeper layers of skin, amplifying the repair response.
Applied after a Facial, PDGF helps the skin hold onto moisture longer and extends the post-treatment glow. It supports gentle cell renewal without irritation.
Used alongside Medical-Grade Skincare, PDGF improves how the skin absorbs active ingredients and reinforces the barrier that keeps moisture in.
Paired with a Chemical Peel, PDGF helps the skin heal evenly, reducing post-peel redness and revealing a clearer, steadier tone.
The cost of PDGF therapy depends on the treatment area, number of sessions, and whether it’s combined with other procedures. During your consultation, we’ll provide a detailed quote so you can make an informed decision.
Platelet-Derived Growth Factor (PDGF) helps the body do what it’s already built to do: repair, rebuild, and renew. Call 617-872-5877 to schedule your consultation at Trubella Medspa and Aesthetics in Dedham and learn how PDGF can fit into your broader skin plan.
Yes. PDGF is FDA-approved for various clinical and cosmetic uses, derived from your own blood, and considered safe for all skin types.
While both come from platelets, PDGF isolates a specific derived growth factor (PDGF-BB) responsible for cell growth, blood vessel formation, and tissue repair, making it more concentrated and targeted than standard PRP therapy.
Most patients see initial brightness and smoother skin within several weeks, with continued improvement as collagen production and tissue regeneration progress.
Yes. By rebuilding the extracellular matrix, PDGF improves skin texture, helping fade acne scars and restore a smoother complexion.
Only minimal downtime—mild redness or swelling may occur briefly, but most clients resume regular activities the same day.
